The draw for the Telkom Knockout draw was conducted on Tuesday evening following the conclusion of the AmaZulu versus Cape Town City match.
Usuthu claimed the last eight spot after overcoming the Blue and Gold Army with a 2-0 win at the King Zwelithini Stadium, courtesy of second half goals by Emiliano Tade and Bonginkosi Ntuli.
Holders Bidvest Wits will face a tricky trip to KwaZulu-Natal to face Maritzburg United.
Telkom Knockout Last 8 Draw:
Maritzburg United vs Bidvest Wits
Kaizer Chiefs vs SuperSport United
AmaZulu vs Orlando Pirates
Baroka FC vs Mamelodi Sundowns
The matches will be played on the weekend of November 3 and 4.
The final will for the first time be staged at the Nelson Mandela Bay Stadium in Port Elizabeth on December 8.