AmaZulu welcome Mamelodi Sundowns to the King Zwelithini Stadium in an Absa Premiership match on Sunday afternoon.
Usuthu are looking to return to winning ways after suffering a heavy 3-0 defeat to PSL log leaders Bidvest Wits away on August 29.
The KwaZulu-Natal outfit are currently in fifth spot on the league standings with six points from four matches having won two matches and losing two.
Masandawana are winless in three matches in all competitions and were last held to a 0-0 draw by newcomers Highlands Park.
Pitso Mosimane’s charges then suffered back-to-back elimination from the CAF Champions League and the MTN8 competition.
The Tshwane giants have only played three matches this season and are placed sixth on the league standings having accumulated five points.
In head-to-head stats, Sundowns and AmaZulu have met in 55 league matches since 1985.
The Brazilians have claimed 36 wins compared to seven for Usuthu, while 12 matches have been drawn.
The Durban side has won just two of their 28 home matches in the rivalry, suffering 20 defeats in the process.
Last season, the teams won in each other’s backyards, with AmaZulu shocking the defending league champions with a 2-1 scoreline in the first half of the campaign.
The return game in Durban saw Sundowns walk away with a 3-1 victory.